Recent therapeutic advancements in managing systemic sclerosis (scleroderma) focus on addressing specific pathogenic mechanisms involved in the disease. These approaches aim to reduce fibrosis, manage vascular complications, and suppress the autoimmune response. The targeted therapies are often tailored to the individual patient’s disease subtype and specific organ involvement.
Progress in this area is critical due to the complex nature of scleroderma, which affects multiple organ systems and significantly impacts quality of life. Historically, treatment has been largely symptomatic and focused on managing complications. Current research aims to identify treatments that can modify the disease course, offering hope for improved long-term outcomes and reduced morbidity.