Ingestion of a nicotine pouch designed for oral placement results in the introduction of nicotine directly into the gastrointestinal tract. Unlike intended use, where nicotine is absorbed through the oral mucosa, swallowing the pouch subjects it to the digestive system. This process involves the stomach’s acidic environment and subsequent enzymatic breakdown in the small intestine, ultimately releasing nicotine for absorption.
The effects stemming from this unintentional ingestion can vary based on factors such as the individual’s weight, tolerance to nicotine, and the specific nicotine content of the pouch. Consequences may include nausea, vomiting, dizziness, increased heart rate, and potential abdominal discomfort. The rate of nicotine absorption can differ compared to buccal absorption, possibly leading to a delayed but more intense onset of symptoms.