Factors influencing the subjective experience of intoxication are numerous and varied. Examples include set and setting, dosage, method of administration, individual physiology, and concurrent substance use. These elements interact in complex ways to shape the overall effect.
Understanding the variables that modulate the altered state of consciousness is critical in harm reduction strategies and responsible use. Historically, different cultures have recognized and leveraged these modulating factors to create specific rituals or experiences surrounding psychoactive substances, focusing on maximizing positive outcomes and minimizing potential risks.
